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Review
. 2016 May;22(5):414-429.
doi: 10.1016/j.molmed.2016.03.002. Epub 2016 Apr 7.

Noncanonical NF-κB Signaling in Health and Disease

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Review

Noncanonical NF-κB Signaling in Health and Disease

Gökhan Cildir et al. Trends Mol Med. .

Abstract

Noncanonical NF-κB signaling differs from canonical NF-κB signaling by being activated through different cell surface receptors, cytoplasmic adaptors, and NF-κB dimers. Under normal physiological conditions, this noncanonical pathway has been implicated in diverse biological processes, including lymphoid organogenesis, B cell maturation, osteoclast differentiation, and various functions of other immune cells. Recently, dysfunction of this pathway has also been causally associated with numerous immune-mediated pathologies and human malignancies. Here, we summarize the core elements as well as the recently identified novel regulators of the noncanonical NF-κB signaling pathway. The involvement of this pathway in different pathologies and the potential therapeutic options that are currently envisaged are also discussed.

Keywords: NIK; non-canonical NF-κB signaling; p52/RelB.

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