Process Pharmacology: A Pharmacological Data Science Approach to Drug Development and Therapy

CPT Pharmacometrics Syst Pharmacol. 2016 Apr;5(4):192-200. doi: 10.1002/psp4.12072. Epub 2016 Mar 24.


A novel functional-genomics based concept of pharmacology that uses artificial intelligence techniques for mining and knowledge discovery in "big data" providing comprehensive information about the drugs' targets and their functional genomics is proposed. In "process pharmacology", drugs are associated with biological processes. This puts the disease, regarded as alterations in the activity in one or several cellular processes, in the focus of drug therapy. In this setting, the molecular drug targets are merely intermediates. The identification of drugs for therapeutic or repurposing is based on similarities in the high-dimensional space of the biological processes that a drug influences. Applying this principle to data associated with lymphoblastic leukemia identified a short list of candidate drugs, including one that was recently proposed as novel rescue medication for lymphocytic leukemia. The pharmacological data science approach provides successful selections of drug candidates within development and repurposing tasks.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analgesics / pharmacology
  • Antihypertensive Agents / pharmacology
  • Antineoplastic Agents / pharmacology
  • Artificial Intelligence
  • Drug Discovery / methods*
  • Drug Repositioning
  • Genomics
  • Humans
  • Molecular Targeted Therapy
  • Pharmacological Phenomena
  • Pharmacology / methods*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics
  • Systems Biology


  • Analgesics
  • Antihypertensive Agents
  • Antineoplastic Agents