Effective Chemical Inactivation of Ebola Virus

Emerg Infect Dis. 2016 Jul;22(7):1292-4. doi: 10.3201/eid2207.160233. Epub 2016 Jul 15.


Reliable inactivation of specimens before removal from high-level biocontainment is crucial for safe operation. To evaluate efficacy of methods of chemical inactivation, we compared in vitro and in vivo approaches using Ebola virus as a surrogate pathogen. Consequently, we have established parameters and protocols leading to reliable and effective inactivation.

Keywords: Ebola virus; chemical inactivation; mouse model; tissue culture; viruses.

MeSH terms

  • Animals
  • Chlorocebus aethiops
  • Disinfectants / pharmacology*
  • Ebolavirus / drug effects*
  • Mice
  • Mice, Inbred BALB C
  • Vero Cells
  • Virus Inactivation / drug effects*


  • Disinfectants