Birdshot Retinochoroidopathy: Differences in Clinical Characteristics between Patients with Early and Late Age of Onset

Ocul Immunol Inflamm. 2017 Oct;25(5):589-595. doi: 10.3109/09273948.2016.1158278. Epub 2016 Apr 12.

Abstract

Purpose: To describe differences in the clinical characteristics of birdshot retinochoroidopathy (BSRC) patients diagnosed early and later in life.

Methods: This is a retrospective cohort study. Age was primarily analyzed and 50 years of age at diagnosis was selected as a cut-off point.

Results: A total of 144 patients (288 eyes) were included; 68 with early-onset and 76 with late-onset BSRC. The younger group had a statistically significant higher rate of more severe iritis (p = 0.04); an average number of non-steroidal immunosuppressants and biologic agents (NSIB) (p = 0.04); and a prolonged time to initiation of NSIB (p = 0.01). There were only four patients (3%) who had >0.5+ cells in the anterior chamber.

Conclusions: Patients with early-onset BSRC carried a higher risk for anterior segment inflammation, had a more prolonged delay to initiation of treatment with NSIB, and required a greater number of NSIBs to achieve remission.

Keywords: Birdshot retinochoroidopathy; early-onset; inflammation; late-onset.

MeSH terms

  • Adult
  • Age Distribution
  • Age of Onset
  • Aged
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Biological Factors / therapeutic use
  • Birdshot Chorioretinopathy
  • Chorioretinitis / diagnosis*
  • Chorioretinitis / drug therapy
  • Cyclosporine / therapeutic use
  • Early Diagnosis
  • Female
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Infliximab / therapeutic use
  • Iritis / diagnosis*
  • Iritis / drug therapy
  • Male
  • Middle Aged
  • Mycophenolic Acid / therapeutic use
  • Retrospective Studies
  • Risk Factors
  • Visual Acuity
  • Young Adult

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Biological Factors
  • Immunosuppressive Agents
  • Cyclosporine
  • Infliximab
  • Mycophenolic Acid

Supplementary concepts

  • Birdshot chorioretinopathy