Clinical Features of Systemic Metastatic Retinal Lymphoma in Japanese Patients

Ocul Immunol Inflamm. 2017 Oct;25(5):654-662. doi: 10.3109/09273948.2016.1151894. Epub 2016 Apr 12.


Purpose: Systemic metastatic retinal lymphoma (SMRL) originates in systemic organs. It has been reported to exhibit clinical features similar to those of primary vitreoretinal lymphoma (PVRL). We report six cases of SMRL in a single-center survey in Japan.

Methods: The clinical and pathologic features in SMRL at the Kyushu University Hospital were retrospectively studied.

Results: The mean patient age at the onset of ocular involvement was 75.3 years. Four patients had brain involvement. The primary sites were: breast (2); chest (1); testis (1); intestinal tract (1); and nasal sinus (1). In all patients, the cytology of vitreous samples indicated diffuse large B-cell lymphoma (DLBCL).

Conclusions: DLBCL is the most common subtype in our study. The prevalence of CNS involvement in patients with SMRL is similar to that with PVRL. The testis and breast may be common sites of origin for SMRL.

Keywords: CNS involvement; Clinical features; primary organs; single-center study; vitreoretinal lymphoma.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Aged, 80 and over
  • Asian People / ethnology
  • Breast Neoplasms / pathology
  • Female
  • Gene Rearrangement
  • Humans
  • Immunoglobulin Heavy Chains / genetics
  • Intestinal Neoplasms / pathology
  • Japan / epidemiology
  • Lymphatic Metastasis*
  • Lymphoma, Large B-Cell, Diffuse / diagnosis*
  • Lymphoma, Large B-Cell, Diffuse / ethnology
  • Lymphoma, Large B-Cell, Diffuse / metabolism
  • Male
  • Neoplasm Proteins / metabolism
  • Paranasal Sinus Neoplasms / pathology
  • Polymerase Chain Reaction
  • Retinal Neoplasms / diagnosis*
  • Retinal Neoplasms / ethnology
  • Retinal Neoplasms / metabolism
  • Retrospective Studies
  • Testicular Neoplasms / pathology
  • Thoracic Neoplasms / pathology
  • Vitrectomy
  • Vitreous Body / pathology


  • Immunoglobulin Heavy Chains
  • Neoplasm Proteins