Estrogen receptors alpha and beta in bone

Aysha B Khalid; Susan A Krum

doi:10.1016/j.bone.2016.03.016

Estrogen receptors alpha and beta in bone

Bone. 2016 Jun:87:130-5. doi: 10.1016/j.bone.2016.03.016. Epub 2016 Apr 9.

Authors

Aysha B Khalid¹, Susan A Krum²

Affiliations

¹ Department of Orthopaedic Surgery and Biomedical Engineering, University of Tennessee Health Science Center, Memphis, TN, United States.
² Department of Orthopaedic Surgery and Biomedical Engineering, University of Tennessee Health Science Center, Memphis, TN, United States. Electronic address: smirand5@uthsc.edu.

Abstract

Estrogens are important for bone metabolism via a variety of mechanisms in osteoblasts, osteocytes, osteoclasts, immune cells and other cells to maintain bone mineral density. Estrogens bind to estrogen receptor alpha (ERα) and ERβ, and the roles of each of these receptors are beginning to be elucidated through whole body and tissue-specific knockouts of the receptors. In vitro and in vivo experiments have shown that ERα and ERβ antagonize each other in bone and in other tissues. This review will highlight the role of these receptors in bone, with particular emphasis on their antagonism.

Keywords: Bone; Estrogen; Estrogen receptor alpha (ERα, ESR1); Estrogen receptor beta (ERβ, ESR2).

Publication types

Review
Research Support, N.I.H., Extramural

MeSH terms

Animals
Bone and Bones / metabolism*
Estrogen Receptor alpha / metabolism*
Estrogen Receptor beta / metabolism*
Gene Expression Regulation
Humans
Osteoblasts / metabolism
Osteoclasts / metabolism

Substances

Estrogen Receptor alpha
Estrogen Receptor beta

Grants and funding

R01 AR064354/AR/NIAMS NIH HHS/United States