History full circle: 'Novel' sympathomimetics in supplements

Drug Test Anal. Mar-Apr 2016;8(3-4):283-6. doi: 10.1002/dta.1852. Epub 2015 Nov 2.

Abstract

Since the banning of ephedrine in over-the-counter nutritional supplements a decade ago, a plethora of untested and/or unsafe sympathomimetic stimulants have taken its place. This paper argues that these 'novel' stimulants in supplements recapitulate the work of synthetic chemists at commercial pharmaceutical firms during the 1930s and 1940s, all seeking substitutes for recently successful products based on ephedrine and amphetamine. Copyright © 2015 John Wiley & Sons, Ltd.

Keywords: amphetamines; drug safety; ephedrine; nutritional supplements; pharmaceutical regulation; substance abuse.

Publication types

  • Historical Article

MeSH terms

  • Amphetamines / administration & dosage
  • Amphetamines / history
  • Central Nervous System Stimulants / administration & dosage
  • Central Nervous System Stimulants / history
  • Dietary Supplements / history*
  • Drug Industry / history
  • Ephedrine / administration & dosage*
  • Ephedrine / history
  • History, 20th Century
  • Humans
  • Sympathomimetics / administration & dosage*
  • Sympathomimetics / history

Substances

  • Amphetamines
  • Central Nervous System Stimulants
  • Sympathomimetics
  • Ephedrine