Intradiscal platelet-rich plasma (PRP) injections for discogenic low back pain: an update

Int Orthop. 2016 Jun;40(6):1321-8. doi: 10.1007/s00264-016-3178-3. Epub 2016 Apr 12.


Purpose: The aim of this article is to provide an overview of clinical and translational research on intradiscal platelet-rich plasma (PRP) as a minimally invasive treatment for discogenic low back pain.

Methods: A literature review of in vitro, in vivo, and clinical studies was performed.

Results: There is strong in vitro evidence that supports the use of intradiscal PRP for discogenic low back pain. There are also promising findings in select preclinical animal studies. A clinical study of 29 participants who underwent intradiscal PRP injections for discogenic low back pain found statistically and clinically significant improvements in pain and function through two years of follow-up.

Conclusions: Intradiscal PRP is a safe and a possibly effective treatment for discogenic low back pain. Future studies are warranted to determine the best candidates for this treatment, what the optimal injectate is and what relationships exist between patient-reported outcomes and radiological findings.

Keywords: Biologic; Disc; Treatments.

Publication types

  • Review

MeSH terms

  • Female
  • Humans
  • Intervertebral Disc / drug effects*
  • Intervertebral Disc Degeneration / complications
  • Intervertebral Disc Degeneration / drug therapy*
  • Intervertebral Disc Displacement / drug therapy
  • Low Back Pain / drug therapy*
  • Low Back Pain / physiopathology
  • Male
  • Platelet-Rich Plasma / drug effects*
  • Treatment Outcome