Iron-Catalyzed Radical [2 + 2 + 2] Annulation of Benzene-Linked 1,7-Enynes with Aldehydes: Fused Pyran Compounds

Leiyang Lv; Zhiping Li

doi:10.1021/acs.orglett.6b00902

Iron-Catalyzed Radical [2 + 2 + 2] Annulation of Benzene-Linked 1,7-Enynes with Aldehydes: Fused Pyran Compounds

Org Lett. 2016 May 6;18(9):2264-7. doi: 10.1021/acs.orglett.6b00902. Epub 2016 Apr 13.

Authors

Leiyang Lv¹, Zhiping Li¹

Affiliation

¹ Department of Chemistry, Renmin University of China , Beijing 100872, China.

PMID: 27074431
DOI: 10.1021/acs.orglett.6b00902

Abstract

An iron-catalyzed radical [2 + 2 + 2] annulation of benzene-linked 1,7-enynes with aldehydes has been developed. With this method, a variety of fused [6.6.6] pyran molecules are built in an efficient and selective manner. The aldehydic radical-mediated strategy exhibits a particularly attractive dual role, which triggers and terminates the domino cyclization.

Publication types

Research Support, Non-U.S. Gov't