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, 133 (1), 93-100

The mRNA Encoding Elongation Factor 1-alpha (EF-1 Alpha) Is a Major Transcript at the Midblastula Transition in Xenopus

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The mRNA Encoding Elongation Factor 1-alpha (EF-1 Alpha) Is a Major Transcript at the Midblastula Transition in Xenopus

P A Krieg et al. Dev Biol.

Abstract

A Xenopus laevis gastrula cDNA library has been screened in order to identify sequences that are expressed early in development. We find that the mRNA encoding translation elongation factor 1-alpha (EF-1 alpha) is synthesized in very large amounts in the early embryo. Transcription of EF-1 alpha mRNA commences at the midblastula transition (MBT), and new EF-1 alpha protein is synthesized very soon after this, as determined by the association of EF-1 alpha mRNA with polysomes. The nucleotide sequence of a full-length EF-1 alpha cDNA clone and the deduced amino acid sequence of Xenopus EF-1 alpha protein are presented.

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