Prognostic significance of whole blood viscosity estimated by de Simone's formula in ST-elevation myocardial infarction

Biomark Med. 2016 May;10(5):495-511. doi: 10.2217/bmm.16.10. Epub 2016 Apr 13.

Abstract

Background: We assessed the predictive value of estimated whole blood viscosity (WBV) in-hospital and long-term cardiovascular outcomes in patients with ST-elevation myocardial infarction (STEMI).

Materials & methods: One thousand eight hundred and thirty-five STEMI patients were followed up for median 34.6 months. WBV was calculated consistent with the de Simone's formula.

Results: In-hospital and long-term major adverse cardiovascular events (MACE) demonstrated an incremental trend in ascending order of WBV tertiles at low and high shear rate. Kaplan-Meier analysis showed a higher occurrence of long-term MACE in third WBV tertiles compared with other tertiles.

Conclusion: WBV seems to be a feasible prognostic indicator of short- and long-term cardiovascular adverse events in patients with STEMI. As an easily available parameter, WBV may be utilized in identifying high-risk patients for subsequent MACE.

Keywords: MACE; ST-elevation myocardial infarction; shear rate; whole blood viscosity.

MeSH terms

  • Aged
  • Algorithms*
  • Area Under Curve
  • Blood Viscosity / physiology*
  • Coronary Angiography
  • Echocardiography
  • Female
  • Follow-Up Studies
  • Hospitalization
  • Humans
  • Kaplan-Meier Estimate
  • Logistic Models
  • Male
  • Middle Aged
  • Prognosis
  • Proportional Hazards Models
  • ROC Curve
  • ST Elevation Myocardial Infarction / diagnosis*
  • ST Elevation Myocardial Infarction / mortality
  • ST Elevation Myocardial Infarction / pathology
  • Sensitivity and Specificity
  • Shear Strength
  • Time Factors