mRNA vaccine delivery using lipid nanoparticles

Ther Deliv. 2016;7(5):319-34. doi: 10.4155/tde-2016-0006.


mRNA vaccines elicit a potent immune response including antibodies and cytotoxic T cells. mRNA vaccines are currently evaluated in clinical trials for cancer immunotherapy applications, but also have great potential as prophylactic vaccines. Efficient delivery of mRNA vaccines will be key for their success and translation to the clinic. Among potential nonviral vectors, lipid nanoparticles are particularly promising. Indeed, lipid nanoparticles can be synthesized with relative ease in a scalable manner, protect the mRNA against degradation, facilitate endosomal escape, can be targeted to the desired cell type by surface decoration with ligands, and as needed, can be codelivered with adjuvants.

Keywords: adjuvant; cancer immunotherapy; cationic lipid; drug delivery; lipid nanoparticle; mRNA; oligonucleotide; therapeutic vaccine; vaccine.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Drug Delivery Systems / methods*
  • Lipids / administration & dosage*
  • Macaca
  • Mice
  • Nanoparticles*
  • RNA, Messenger / administration & dosage*
  • Rabbits
  • Vaccines / administration & dosage*


  • Lipids
  • RNA, Messenger
  • Vaccines