The Plot Thickens: Diet Microbe Interactions May Modulate Thrombosis Risk

Ana Martínez-Del Campo; Kymberleigh A Romano; Federico E Rey; Emily P Balskus

doi:10.1016/j.cmet.2016.03.017

The Plot Thickens: Diet Microbe Interactions May Modulate Thrombosis Risk

Cell Metab. 2016 Apr 12;23(4):573-5. doi: 10.1016/j.cmet.2016.03.017.

Authors

Ana Martínez-Del Campo¹, Kymberleigh A Romano², Federico E Rey², Emily P Balskus³

Affiliations

¹ Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
² Department of Bacteriology, University of Wisconsin-Madison, Madison, WI 53706, USA.
³ Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA. Electronic address: balskus@chemistry.harvard.edu.

PMID: 27076072
DOI: 10.1016/j.cmet.2016.03.017

Abstract

Thrombosis plays an important role in cardiovascular disease (CVD). Platelet activation is an essential step in the genesis and propagation of atherothrombotic complications. In a recent publication, Zhu and colleagues report that gut microbe-derived TMAO enhances platelet responsiveness and thrombosis, providing a novel mechanistic connection between microbes and CVD (Zhu et al., 2016).

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MeSH terms

Cardiovascular Diseases
Diet*
Humans
Microbial Interactions
Thrombosis*