Effect of Recombinant Human Growth Hormone and Rosiglitazone for HIV-Associated Abdominal Fat Accumulation on Adiponectin and other Markers of Inflammation

HIV Clin Trials. 2016 Mar;17(2):55-62. doi: 10.1080/15284336.2015.1126424. Epub 2016 Feb 1.


Background/objective: In a previous report of HIV-infected patients with fat redistribution, we found that recombinant human growth hormone (rhGH) therapy reduced visceral adipose tissue (VAT) but increased insulin resistance, and that the addition of rosiglitazone reversed the negative effects of rhGH on insulin sensitivity. In this study, we sought to determine the effects of rhGH and rosiglitazone therapy on an array of inflammatory and fibrinolytic markers.

Methods: 72 patients with HIV-associated abdominal obesity and insulin resistance were randomized to treatment with rhGH, rosiglitazone, the combination of rhGH and rosiglitazone, or placebo for 12 weeks. Subjects with plasma and serum samples available at weeks 0 (n=63) and 12 (n=46-48) were assessed for adiponectin, C-reactive protein, homocysteine, interleukin-1, interleukin-6, tumor necrosis factor alpha, interferon gamma, fibrinogen, plasminogen activator inhibitor-1 antigen, and tissue plasminogen activator antigen.

Results: Treatment with both rosiglitazone alone and the combination of rosiglitazone and rhGH for 12 weeks resulted in significant increases in adiponectin levels from baseline. Adiponectin levels did not change significantly in the rhGH arm alone . There were no significant changes in the other biomarkers among the different treatment groups.

Discussion: In this study of HIV-infected patients with altered fat distribution, treatment with rosiglitazone had beneficial effects on adiponectin concentrations, an effect that was also seen with a combination of rosiglitazone and rhGH. RhGH administration alone, however, did not demonstrate any significant impact on adiponectin levels despite reductions in VAT.

Keywords: Adiponectin; HIV-1; Human growth hormone; Lipodystrophy; Rosiglitazone.

Publication types

  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural

MeSH terms

  • Abdominal Fat / drug effects
  • Abdominal Fat / metabolism*
  • Adiponectin / blood*
  • Adult
  • Aged
  • Biomarkers / blood
  • Blood Glucose / metabolism
  • C-Reactive Protein / metabolism
  • Drug Therapy, Combination
  • Female
  • HIV Infections / complications*
  • HIV Infections / immunology
  • HIV Infections / metabolism
  • Human Growth Hormone / administration & dosage*
  • Humans
  • Hypoglycemic Agents / administration & dosage*
  • Interleukin-6 / blood
  • Male
  • Middle Aged
  • Obesity / drug therapy*
  • Obesity / etiology
  • Obesity / immunology
  • Obesity / metabolism
  • Rosiglitazone
  • Thiazolidinediones / administration & dosage*
  • Young Adult


  • Adiponectin
  • Biomarkers
  • Blood Glucose
  • Hypoglycemic Agents
  • IL6 protein, human
  • Interleukin-6
  • Thiazolidinediones
  • Rosiglitazone
  • Human Growth Hormone
  • C-Reactive Protein