Breathless in the Gut: Implications of Luminal O2 for Microbial Pathogenicity

Caleb J Kelly; Sean P Colgan

doi:10.1016/j.chom.2016.03.014

Breathless in the Gut: Implications of Luminal O2 for Microbial Pathogenicity

Cell Host Microbe. 2016 Apr 13;19(4):427-8. doi: 10.1016/j.chom.2016.03.014.

Authors

Caleb J Kelly¹, Sean P Colgan²

Affiliations

¹ Department of Medicine and the Mucosal Inflammation Program, University of Colorado School of Medicine, 12700 East 19th Avenue, MS B-146, Aurora, CO 80045, USA.
² Department of Medicine and the Mucosal Inflammation Program, University of Colorado School of Medicine, 12700 East 19th Avenue, MS B-146, Aurora, CO 80045, USA. Electronic address: sean.colgan@ucdenver.edu.

Abstract

Salmonella employs a variety of strategies to survive and colonize the colon. In this issue of Cell Host & Microbe, Rivera-Chávez et al. (2016) identify a new mechanism whereby antibiotic-mediated depletion of anaerobes (e.g., Clostridia) and associated decreases in butyrate result in increased tissue oxygen and increased aerobic expansion of Salmonella.

Publication types

Comment

MeSH terms

Anti-Bacterial Agents
Clostridium
Colon*
Humans
Salmonella*
Virulence

Substances

Anti-Bacterial Agents

Abstract

Publication types

MeSH terms

Substances

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