The third histamine receptor. Highly potent and selective ligands

Int Arch Allergy Appl Immunol. 1989;88(1-2):79-81. doi: 10.1159/000234753.

Abstract

The third histamine receptor was first identified on brain neurons and seems also to be present in other cells such as the lung mast cells. Hence the novel and potent H3 receptor agonist (R)-alpha-methylhistamine might find therapeutic applications in allergic diseases.

MeSH terms

  • Animals
  • Brain / physiology
  • Guinea Pigs
  • In Vitro Techniques
  • Ligands
  • Lung / physiology
  • Mast Cells / physiology
  • Methylhistamines / pharmacology*
  • Piperidines / pharmacology
  • Rats
  • Receptors, Histamine / classification
  • Receptors, Histamine / drug effects
  • Receptors, Histamine / metabolism*
  • Stereoisomerism
  • Structure-Activity Relationship

Substances

  • Ligands
  • Methylhistamines
  • Piperidines
  • Receptors, Histamine
  • thioperamide