Single-cell profiling of lncRNAs in the developing human brain

Genome Biol. 2016 Apr 14:17:68. doi: 10.1186/s13059-016-0933-0.

Abstract

Single-cell RNA-seq in samples from the human neocortex demonstrate that long noncoding RNAs (lncRNAs) are abundantly expressed in specific individual brain cells, despite being hard to detect in bulk samples. This result suggests that the lncRNAs might have important functions in specific cell types in the brain.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Brain
  • Gene Expression Profiling*
  • Humans
  • RNA, Long Noncoding*

Substances

  • RNA, Long Noncoding