Extended antibiotic resistance in carbapenemase-producing Klebsiella pneumoniae: A case series

Am J Infect Control. 2016 Sep 1;44(9):1050-2. doi: 10.1016/j.ajic.2016.02.018. Epub 2016 Apr 11.

Abstract

Infections caused by carbapenemase-producing Klebsiella pneumoniae resistant to tigecycline, colistin, or aminoglycosides are a growing health concern. In our retrospective chart review, we noted increased resistance to colistin compared with tigecycline, despite limited prior use of colistin. This may affect the choice of presumptive antibiotics used in these hard to treat infections. Improved infection control and antimicrobial stewardship practices are essential to prevent the spread of these multidrug-resistant organisms.

Keywords: Klebsiella pneumoniae; colistin; drug resistance.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Anti-Bacterial Agents / pharmacology
  • Bacterial Proteins / metabolism*
  • Colistin / pharmacology
  • Drug Resistance, Multiple, Bacterial*
  • Female
  • Humans
  • Klebsiella Infections / microbiology*
  • Klebsiella pneumoniae / drug effects*
  • Klebsiella pneumoniae / enzymology*
  • Klebsiella pneumoniae / isolation & purification
  • Male
  • Middle Aged
  • Minocycline / analogs & derivatives
  • Minocycline / pharmacology
  • Retrospective Studies
  • Tigecycline
  • Young Adult
  • beta-Lactamases / metabolism*

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Tigecycline
  • beta-Lactamases
  • carbapenemase
  • Minocycline
  • Colistin