Nonallergic Rhinitis: Mechanism of Action

Immunol Allergy Clin North Am. 2016 May;36(2):279-87. doi: 10.1016/j.iac.2015.12.005. Epub 2016 Mar 5.

Abstract

Nonallergic rhinitis is a common disease that affects many Americans. It is characterized by nasal symptoms of congestion and rhinorrhea without evidence of allergic sensitization. The pathophysiology of the disease has not been studied extensively. In the following article, the author concentrates on summarizing the available information related to cellular inflammation and neurogenic mechanisms in patients with nonallergic rhinitis. The author also explores nasal reactivity to various stimuli in these patients.

Keywords: Cold-dry air; Histamine; Neurogenic; Nonallergic rhinitis; Reactivity.

Publication types

  • Review

MeSH terms

  • Humans
  • Hypersensitivity
  • Nasal Mucosa / pathology
  • Rhinitis / classification
  • Rhinitis / diagnosis
  • Rhinitis / pathology*