Enhancement of anti-inflammatory activity of bromelain by its encapsulation in katira gum nanoparticles

Carbohydr Polym. 2016 Jun 5:143:18-24. doi: 10.1016/j.carbpol.2016.01.055. Epub 2016 Jan 28.

Abstract

Bromelain-loaded katira gum nanoparticles were synthesized using 3 level optimization process and desirability approach. Nanoparticles of the optimized batch were characterized using particle size analysis, zeta potential, transmission electron microscopy and Fourier-transform infrared spectroscopy. Investigation of their in vivo anti-inflammatory activity by employing carrageenan induced rat-paw oedema method showed that encapsulation of bromelain in katira gum nanoparticles substantially enhanced its anti-inflammatory potential. This may be attributed to enhanced absorption owing to reduced particle size or to protection of bromelain from acid proteases.

Keywords: Bromelain; Cochlospermum religiosum; FTIR; Katira gum; Nanoparticles.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / chemistry
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
  • Bixaceae / chemistry*
  • Bromelains / chemistry
  • Bromelains / therapeutic use*
  • Calcium Chloride
  • Carrageenan
  • Diclofenac / therapeutic use
  • Drug Compounding
  • Edema / chemically induced
  • Edema / drug therapy
  • Female
  • Magnesium Chloride
  • Male
  • Nanoparticles
  • Particle Size
  • Plant Gums / chemistry*
  • Rats
  • Rats, Wistar

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Plant Gums
  • Magnesium Chloride
  • Diclofenac
  • Carrageenan
  • Bromelains
  • stem bromelain
  • Calcium Chloride