Mania associated with ranitidine: a case report and review of literature

Fundam Clin Pharmacol. 2016 Aug;30(4):294-6. doi: 10.1111/fcp.12201. Epub 2016 May 5.

Abstract

H2 receptor antagonists can be associated with central adverse drug reactions (ADRs), like confusion, delirium, hallucinations, slurred speech or headaches. We report here a 'serious' case of severe mania leading to hospitalization in a 42-year-old alcohol-dependent man, 4 days after ranitidine introduction. Review of literature showed that this 'very rare' ADR occurs mainly in patients with predisposing factors: age, decrease in renal and/or hepatic function, polymedication, alcohol. Knowledge of this ADR can be particularly important for these drugs widely used as self-medication.

Keywords: H2 receptor antagonists; mania; psychiatric adverse drug reactions; ranitidine; self-medication.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Bipolar Disorder / chemically induced*
  • Bipolar Disorder / diagnosis*
  • Histamine H2 Antagonists / adverse effects*
  • Humans
  • Male
  • Ranitidine / adverse effects*

Substances

  • Histamine H2 Antagonists
  • Ranitidine