Adaptive immunity in HBV infection

J Hepatol. 2016 Apr;64(1 Suppl):S71-S83. doi: 10.1016/j.jhep.2016.01.026.


During hepatitis B virus (HBV) infection, the presence of HBV-specific antibody producing B cells and functional HBV-specific T cells (with helper or cytotoxic effects) ultimately determines HBV infection outcome. In this review, in addition to summarizing the present state of knowledge of HBV-adaptive immunity, we will highlight controversies and uncertainties concerning the HBV-specific B and T lymphocyte response, and propose future directions for research aimed at the generation of more efficient immunotherapeutic strategies.

Keywords: Antiviral immunity; B lymphocytes; Immunodominance; T cell exhaustion; T lymphocytes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptive Immunity*
  • Antiviral Agents / therapeutic use*
  • Hepatitis B Core Antigens / immunology*
  • Hepatitis B Surface Antigens / immunology*
  • Hepatitis B virus / immunology*
  • Hepatitis B, Chronic / drug therapy
  • Hepatitis B, Chronic / immunology
  • Hepatitis B, Chronic / virology*
  • Humans
  • T-Lymphocytes / immunology*


  • Antiviral Agents
  • Hepatitis B Core Antigens
  • Hepatitis B Surface Antigens