Role of antifungal medicaments added to tissue conditioners: A systematic review

J Prosthodont Res. 2016 Oct;60(4):231-239. doi: 10.1016/j.jpor.2016.03.006. Epub 2016 Apr 13.


Purpose: The aim of this review is to investigate the current state of knowledge on the incorporation of antifungal agents into the tissue conditioners for the treatment of denture induced stomatitis.

Study selection: Studies reporting the incorporation of antifungal/antimicrobial agents in to tissue conditioners were included in the review. In order to search the studies on the topic "incorporation of antifungal agents in tissue conditioners for the treatment of denture induced stomatitis" ISI web of science, PubMed/MEDLINE, and Google-Scholar databases were searched from 1970 up to and including July 2015 using various keywords such as antifungal agents, tissue conditioners, Candida albicans, denture stomatitis, etc.

Results: Various studies reported the efficacy and effectiveness of adding conventional organic antifungal medicines (nystatin, azole group derivatives and chlorhexidine, antimicrobials/antifungals other than organic (silver zeolite, silver nano-particles, photo-catalysts and metallic oxides) and natural and herbal antimicrobials (tea tree oil, lemongrass essential oil and origanum oil) into various tissue conditioners. The review literature reported that incorporation of antifungal agents into tissue conditioners is effective with minimal or no effects on physical and mechanical properties of tissue conditioners.

Conclusions: Incorporation of different antifungal medicaments to commercially available tissue conditioners can be recommended for the management of denture induced stomatitis.

Keywords: Candida albicans; Denture stomatitis; Prosthesis; Tissue conditioners.

Publication types

  • Meta-Analysis
  • Review
  • Systematic Review

MeSH terms

  • Anti-Infective Agents / administration & dosage*
  • Antifungal Agents / administration & dosage*
  • Candidiasis, Oral
  • Databases, Bibliographic
  • Dentures / adverse effects*
  • Humans
  • Stomatitis, Denture / drug therapy*
  • Stomatitis, Denture / etiology
  • Stomatitis, Denture / microbiology
  • Stomatitis, Denture / prevention & control*
  • Tissue Conditioning, Dental*


  • Anti-Infective Agents
  • Antifungal Agents