Mangiferin: a promising anticancer bioactive

Pharm Pat Anal. 2016 May;5(3):169-81. doi: 10.4155/ppa-2016-0003. Epub 2016 Apr 18.


Of late, several biologically active antioxidants from natural products have been investigated by the researchers in order to combat the root cause of carcinogenesis, in other words, oxidative stress. Mangiferin, a therapeutically active C-glucosylated xanthone, is extracted from pulp, peel, seed, bark and leaf of Mangifera indica. These polyphenols of mangiferin exhibit antioxidant properties and tend to decrease the oxygen-free radicals, thereby reducing the DNA damage. Indeed, its capability to modulate several key inflammatory pathways undoubtedly helps in stalling the progression of carcinogenesis. The current review article emphasizes an updated account on the patents published on the chemopreventive action of mangiferin, apoptosis induction made on various cancer cells, along with proposed antioxidative activities and patent mapping of other important therapeutic properties. Considering it as promising polyphenol, this paper would also summarize the diverse molecular targets of mangiferin.

Keywords: anti-inflammatory; antioxidants; apoptosis; bioactive; chemoprotective; homomangiferin; isomangiferin; multiple molecular targets.

Publication types

  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents* / chemistry
  • Antineoplastic Agents* / isolation & purification
  • Antineoplastic Agents* / pharmacology
  • Antineoplastic Agents* / therapeutic use
  • Antioxidants* / chemistry
  • Antioxidants* / isolation & purification
  • Antioxidants* / pharmacology
  • Antioxidants* / therapeutic use
  • Humans
  • Patents as Topic*
  • Xanthones* / chemistry
  • Xanthones* / isolation & purification
  • Xanthones* / pharmacology
  • Xanthones* / therapeutic use


  • Antineoplastic Agents
  • Antioxidants
  • Xanthones
  • mangiferin