Coordinated grid and place cell replay during rest

Nat Neurosci. 2016 Jun;19(6):792-4. doi: 10.1038/nn.4291. Epub 2016 Apr 18.


Hippocampal replay has been hypothesized to underlie memory consolidation and navigational planning, yet the involvement of grid cells in replay is unknown. During replay we found grid cells to be spatially coherent with place cells, encoding locations 11 ms delayed relative to the hippocampus, with directionally modulated grid cells and forward replay exhibiting the greatest coherence with the CA1 area of the hippocampus. This suggests grid cells are engaged during the consolidation of spatial memories to the neocortex.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials / physiology*
  • Animals
  • Hippocampus / cytology*
  • Male
  • Memory / physiology*
  • Models, Animal
  • Models, Neurological
  • Place Cells / physiology*
  • Rats
  • Rest*
  • Space Perception / physiology
  • Wakefulness / physiology