Vitamin-D measurement in patients with adolescent idiopathic scoliosis

J Pediatr Orthop B. 2017 Jan;26(1):48-52. doi: 10.1097/BPB.0000000000000320.


Our retrospective study compared vitamin-D levels in 229 patients with adolescent idiopathic scoliosis (AIS) and 389 age-matched controls, and evaluated the correlation between vitamin-D levels and sex, Cobb's angle, and serum levels of calcium (Ca), phosphorus, and alkaline phosphatase in the AIS group. Vitamin-D levels were lower in the AIS group, with no sex-specific effects, indicative of a possible vitamin-D resistance in AIS. Vitamin-D levels correlated positively with Ca levels and negatively with Cobb's angle, indicative of a possible role of vitamin D in the etiopathogenesis of AIS. Patients with AIS should be monitored for vitamin-D deficiency/insufficiency.

MeSH terms

  • Adolescent
  • Alkaline Phosphatase / blood
  • Calcium / blood
  • Case-Control Studies
  • Child
  • Female
  • Humans
  • Male
  • Retrospective Studies
  • Scoliosis / blood*
  • Sex Factors
  • Vitamin D / blood*
  • Vitamin D Deficiency / blood
  • Young Adult


  • Vitamin D
  • Alkaline Phosphatase
  • Calcium