The relationship between serum lectin-like oxidized LDL receptor-1 levels and systolic heart failure

Acta Cardiol. 2016 Apr;71(2):185-90. doi: 10.2143/AC.71.2.3141848.


Objectives: Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) appears to be involved in atherosclerotic plaque vulnerability and rupture. In this study, we aimed to evaluate the utility of serum LOX-1 levels in the diagnosis and assessment of left ventricular systolic HF and LOX-1’s relationship with serum pro-brain natriuretic peptide (NT-proBNP).

Design and settings: This was a cross-sectional study of all eligible patients admitted to the department of cardiology of the University Hospital between July 2011 and April 2012.

Methods: Fifty-five patients with a diagnosis of systolic heart failure and 25 patients without systolic HF were enrolled in this study. Serum C-reactive protein, NT-proBNP, and LOX-1 were studied.

Results: Serum LOX-1 and NT-proBNP levels were significantly higher in the heart failure group and showed a positive correlation with NT-proBNP and negative correlations with left ventricular ejection fraction (EF). In addition, LOX-1 levels in patients with ischaemic cardiomyopathy were significantly higher, while they were similar in patients with dilated cardiomyopathy compared to control subjects.

Conclusion: Our study demonstrates the utility of the serum LOX-1 levels in the diagnosis of left ventricular systolic heart failure. LOX-1 may have a place in the diagnosis of heart failure, in particular in patients with ischaemic cardiomyopathy.

Keywords: Left ventricular systolic heart failure; NT pro-brain natriuretic peptide; ejection fraction; lectin-like oxidized LDL receptor-1.

MeSH terms

  • Aged
  • Cross-Sectional Studies
  • Female
  • Heart Failure, Systolic* / blood
  • Heart Failure, Systolic* / diagnosis
  • Heart Failure, Systolic* / physiopathology
  • Humans
  • Male
  • Middle Aged
  • Natriuretic Peptide, Brain / blood*
  • Peptide Fragments / blood*
  • Prognosis
  • Reproducibility of Results
  • Scavenger Receptors, Class E / blood*
  • Statistics as Topic
  • Stroke Volume
  • Turkey
  • Ventricular Dysfunction, Left / physiopathology*


  • Peptide Fragments
  • Scavenger Receptors, Class E
  • pro-brain natriuretic peptide (1-76)
  • Natriuretic Peptide, Brain