Effect of cannabinoids on spasticity and ataxia in multiple sclerosis

J Neurol. 1989 Feb;236(2):120-2. doi: 10.1007/BF00314410.


The chronic motor handicaps of a 30-year-old multiple sclerosis patient acutely improved while he smoked a marihuana cigarette. This effect was quantitatively assessed by means of clinical rating, electromyographic investigation of the leg flexor reflexes and electromagnetic recording of the hand action tremor. It is concluded that cannabinoids may have powerful beneficial effects on both spasticity and ataxia that warrant further evaluation.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Ataxia / drug therapy*
  • Ataxia / etiology
  • Cannabinoids / therapeutic use*
  • Cannabis*
  • Humans
  • Male
  • Multiple Sclerosis / complications
  • Multiple Sclerosis / drug therapy*
  • Muscle Spasticity / drug therapy*
  • Muscle Spasticity / etiology


  • Cannabinoids