Single-cell epigenomics: powerful new methods for understanding gene regulation and cell identity

Genome Biol. 2016 Apr 18;17:72. doi: 10.1186/s13059-016-0944-x.


Emerging single-cell epigenomic methods are being developed with the exciting potential to transform our knowledge of gene regulation. Here we review available techniques and future possibilities, arguing that the full potential of single-cell epigenetic studies will be realized through parallel profiling of genomic, transcriptional, and epigenetic information.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • DNA Methylation
  • Epigenomics / methods*
  • Gene Expression Regulation
  • Humans
  • Single-Cell Analysis / methods*