High therapeutic potential of Spilanthes acmella: A review

EXCLI J. 2013 Apr 4;12:291-312. eCollection 2013.


Spilanthes acmella, a well known antitoothache plant with high medicinal usages, has been recognized as an important medicinal plant and has an increasingly high demand worldwide. From its traditional uses in health care and food, extensive phytochemical studies have been reported. This review provides an overview and general description of the plant species, bioactive metabolites and important pharmacological activities including the preparation, purification and in vitro large-scale production. Structure-activity relationships of the bioactive compounds have been discussed. Considering data from the literature, it could be demonstrated that S. acmella possesses diverse bioactive properties and immense utilization in medicine, health care, cosmetics and as health supplements. As a health food, it is enriched with high therapeutic value with high potential for further development.

Keywords: Spilanthes acmella; bioactive metabolites; bioactivities; in vitro production; structure-activity relationships.

Publication types

  • Review