Stability of vinca alkaloid anticancer drugs in three commonly used infusion fluids

J Parenter Sci Technol. 1989 Mar-Apr;43(2):84-7.


The chemical stabilities of the vinca alkaloid anticancer drugs vinblastine, vincristine, and vindesine have been studied in three commonly used infusion fluids at 4 and 25 degrees C. The infusion fluids were: 0.9% sodium chloride, 5% dextrose, and Ringer's Lactate injection. Stability has been measured by using a stability-indicating high performance liquid chromatographic assay with ultraviolet detection. At 4 degrees C no significant degradation of the vinca alkaloids occurred within a storage period of three weeks. The stability tests at 25 degrees C also revealed that vinblastine, vincristine, and vindesine are stable (greater than 95% remained) when stored for three weeks at this temperature in 5% dextrose, 0.9% sodium chloride, or Ringer's Lactate infusion fluids.

MeSH terms

  • Chromatography, High Pressure Liquid
  • Drug Stability
  • Infusions, Parenteral
  • Solutions
  • Vinca Alkaloids*


  • Solutions
  • Vinca Alkaloids