Adipose derived stem cells for regenerative therapy in osteoarticular diseases

Horm Mol Biol Clin Investig. 2016 Dec 1;28(3):113-120. doi: 10.1515/hmbci-2016-0010.


In the recent years, adipose derived stem cells (ASCs) led to significant findings in the field of regenerative therapy. ASCs have various biological properties and capacity as differentiation in three lineages (chondrocytes, osteocytes and adipocytes) or immunomodulation by releasing paracrine factors. Osteoarthritis (OA) is the most frequent osteoarticular disease characterized by none curative treatment. We reviewed all current data on the proof of concept of ASCs in OA pathophysiology as well as an inventory of ASC promising cell therapy in OA.

Publication types

  • Review

MeSH terms

  • Adipocytes / cytology*
  • Bone Diseases / therapy*
  • Humans
  • Joint Diseases / therapy*
  • Regenerative Medicine*
  • Stem Cell Transplantation / methods*
  • Stem Cells / cytology*