Centromeres of a Different CAL-ibre

Dev Cell. 2016 Apr 18;37(2):105-6. doi: 10.1016/j.devcel.2016.04.006.


Centromeres of higher eukaryotes are defined by the epigenetic inheritance of the centromere-specific CENP-A nucleosome. Reporting in Developmental Cell, Rosin and Mellone (2016) show that co-evolution of the CENP-A histone variant and its chaperone CAL1 accounts for species incompatibility between centromeric histones in Drosophila.

Publication types

  • Comment

MeSH terms

  • Animals
  • Centromere*
  • Drosophila
  • Drosophila Proteins
  • Histones*
  • Nucleosomes


  • Drosophila Proteins
  • Histones
  • Nucleosomes