High-field dissolution dynamic nuclear polarization of [1-(13)C]pyruvic acid

Phys Chem Chem Phys. 2016 May 14;18(18):12409-13. doi: 10.1039/c6cp00589f. Epub 2016 Apr 19.


[1-(13)C]pyruvate is the most widely used hyperpolarized metabolic magnetic resonance imaging agent. Using a custom-built 7.0 T polarizer operating at 1.0 K and trityl radical-doped [1-(13)C]pyruvic acid, unextrapolated solution-state (13)C polarization greater than 60% was measured after dissolution and rapid transfer to a spectrometer magnet, demonstrating the signal enhancement attainable using optimized hardware. Slower rates of polarization under these conditions can be largely overcome with higher radical concentrations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carbon Isotopes / chemistry
  • Gadolinium / chemistry
  • Magnetic Resonance Spectroscopy
  • Microwaves
  • Pyruvic Acid / chemistry*


  • Carbon Isotopes
  • Pyruvic Acid
  • Gadolinium