PGC-1α, glucose metabolism and type 2 diabetes mellitus

Haijiang Wu; Xinna Deng; Yonghong Shi; Ye Su; Jinying Wei; Huijun Duan

doi:10.1530/JOE-16-0021

PGC-1α, glucose metabolism and type 2 diabetes mellitus

J Endocrinol. 2016 Jun;229(3):R99-R115. doi: 10.1530/JOE-16-0021. Epub 2016 Apr 19.

Authors

Haijiang Wu¹, Xinna Deng², Yonghong Shi¹, Ye Su³, Jinying Wei¹, Huijun Duan⁴

Affiliations

¹ Department of PathologyHebei Medical University, Shijiazhuang, China Key Laboratory of Kidney Diseases of Hebei ProvinceShijiazhuang, China.
² Departments of Oncology & ImmunotherapyHebei General Hospital, Shijiazhuang, China.
³ Mathew Mailing Centre for Translational Transplantation StudiesLawson Health Research Institute, London Health Sciences Centre, London, Ontario, Canada Departments of Medicine and PathologyUniversity of Western Ontario, London, Ontario, Canada.
⁴ Department of PathologyHebei Medical University, Shijiazhuang, China Key Laboratory of Kidney Diseases of Hebei ProvinceShijiazhuang, China duanhuijun999@163.com.

PMID: 27094040
DOI: 10.1530/JOE-16-0021

Abstract

Type 2 diabetes mellitus (T2DM) is a chronic disease characterized by glucose metabolic disturbance. A number of transcription factors and coactivators are involved in this process. Peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) is an important transcription coactivator regulating cellular energy metabolism. Accumulating evidence has indicated that PGC-1α is involved in the regulation of T2DM. Therefore, a better understanding of the roles of PGC-1α may shed light on more efficient therapeutic strategies. Here, we review the most recent progress on PGC-1α and discuss its regulatory network in major glucose metabolic tissues such as the liver, skeletal muscle, pancreas and kidney. The significant associations between PGC-1α polymorphisms and T2DM are also discussed in this review.

Keywords: PGC-1α; glucose metabolism; polymorphism; type 2 diabetes mellitus.

Publication types

Review

MeSH terms

AMP-Activated Protein Kinases / metabolism
Diabetes Mellitus, Type 2 / etiology
Diabetes Mellitus, Type 2 / genetics
Diabetes Mellitus, Type 2 / metabolism*
Diabetic Nephropathies / metabolism
Glucocorticoids / metabolism
Glucose / metabolism*
Hepatitis C / complications
Hepatocyte Nuclear Factor 4 / metabolism
Humans
Insulin / metabolism
Insulin Secretion
Insulin-Secreting Cells / metabolism
Insulin-Secreting Cells / pathology
Liver / metabolism
Muscle, Skeletal / metabolism
Oxidative Stress
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / genetics
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / metabolism*
Polymorphism, Genetic
Receptors, Estrogen / metabolism
Signal Transduction
Sirtuins / metabolism
p38 Mitogen-Activated Protein Kinases / metabolism

Substances

Glucocorticoids
HNF4A protein, human
Hepatocyte Nuclear Factor 4
Insulin
PPARGC1A protein, human
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
Receptors, Estrogen
p38 Mitogen-Activated Protein Kinases
AMP-Activated Protein Kinases
Sirtuins
Glucose