Carrots, tomatoes and cocoa: Research on dietary antioxidants in Düsseldorf

Arch Biochem Biophys. 2016 Apr 1;595:125-31. doi: 10.1016/


Dietary antioxidants, their biological effects and underlying mechanisms of action are key topics of research at the Institute of Biochemistry and Molecular Biology I at the Heinrich-Heine University in Düsseldorf where Helmut Sies is active now since more than 35 years. In the present article his research activity on carotenoids is summarized including studies on their bioavailability, antioxidant properties, cellular signaling and dermatological effects. Additionally, comparable studies on cocoa polyphenols are described.

Keywords: Antioxidants; Carotenoids; Flavonoids; Lycopene; Polyphenols; Skin.

Publication types

  • Review

MeSH terms

  • Animals
  • Antioxidants / metabolism*
  • Biological Availability
  • Cacao / metabolism*
  • Carotenoids / pharmacokinetics
  • Daucus carota / metabolism*
  • Gap Junctions / physiology
  • Humans
  • Lycopersicon esculentum / metabolism*


  • Antioxidants
  • Carotenoids