De Novo Malignancies After Transplantation: Risk and Surveillance Strategies

Med Clin North Am. 2016 May;100(3):551-67. doi: 10.1016/j.mcna.2016.01.006. Epub 2016 Mar 17.

Abstract

De novo malignancies are one of the leading causes of late mortality after liver and kidney transplantation. Nonmelanoma skin cancer is the most common malignancy, followed by posttransplant lymphoproliferative disorder and solid organ tumors. Immunosuppression is a key factor for cancer development, although many other transplant-related and traditional risk factors also play a role. In this review, the authors summarize risk factors and outcomes of frequently encountered de novo malignancies after liver and kidney transplantation to stratify recipients at highest risk. Future efforts in prospectively validated, cost-effective surveillance strategies that improve survival of these complex patients are greatly needed.

Keywords: Incidence; Mortality; Posttransplant lymphoproliferative disorder; Risk factors; Skin cancer; Solid organ tumors; Surveillance.

Publication types

  • Review

MeSH terms

  • Cause of Death
  • Humans
  • Immunosuppression / adverse effects
  • Kidney Transplantation* / mortality
  • Liver Transplantation* / mortality
  • Neoplasms / diagnosis
  • Neoplasms / etiology*
  • Neoplasms / mortality
  • Neoplasms / therapy
  • Population Surveillance
  • Postoperative Complications / diagnosis
  • Postoperative Complications / etiology*
  • Postoperative Complications / mortality
  • Postoperative Complications / therapy
  • Risk Factors
  • Survival Rate