UK guideline for the use of HIV Post-Exposure Prophylaxis Following Sexual Exposure, 2015

Int J STD AIDS. 2016 Aug;27(9):713-38. doi: 10.1177/0956462416641813. Epub 2016 Apr 19.


We present the updated British Association for Sexual Health and HIV guidelines for HIV post-exposure prophylaxis following sexual exposure (PEPSE). This document includes a review of the current data to support the use of PEPSE, considers how to calculate the risks of infection after a potential exposure, and provides recommendations on when PEPSE should and should not be considered. We also review which medications to use for PEPSE, provide a checklist for initial assessment, and make recommendations for monitoring individuals receiving PEPSE. Special scenarios, cost-effectiveness of PEPSE, and issues relating to service provision are also discussed. Throughout the document, the place of PEPSE within the broader context of other HIV prevention strategies is considered.

Keywords: AIDS; BASHH guidelines; HIV; HIV prevention; Post-exposure prophylaxis (PEP); antiretroviral therapy; sexual exposure.

MeSH terms

  • Anti-HIV Agents / administration & dosage*
  • Anti-HIV Agents / economics
  • Coitus
  • Cost-Benefit Analysis
  • Female
  • HIV Infections / prevention & control*
  • Humans
  • Male
  • Post-Exposure Prophylaxis* / economics
  • Practice Guidelines as Topic*
  • Risk Assessment
  • Risk Factors
  • Sexual Behavior*
  • United Kingdom


  • Anti-HIV Agents