Nutrigenomics, the Microbiome, and Gene-Environment Interactions: New Directions in Cardiovascular Disease Research, Prevention, and Treatment: A Scientific Statement From the American Heart Association

Circ Cardiovasc Genet. 2016 Jun;9(3):291-313. doi: 10.1161/HCG.0000000000000030. Epub 2016 Apr 19.


Cardiometabolic diseases are the leading cause of death worldwide and are strongly linked to both genetic and nutritional factors. The field of nutrigenomics encompasses multiple approaches aimed at understanding the effects of diet on health or disease development, including nutrigenetic studies investigating the relationship between genetic variants and diet in modulating cardiometabolic risk, as well as the effects of dietary components on multiple "omic" measures, including transcriptomics, metabolomics, proteomics, lipidomics, epigenetic modifications, and the microbiome. Here, we describe the current state of the field of nutrigenomics with respect to cardiometabolic disease research and outline a direction for the integration of multiple omics techniques in future nutrigenomic studies aimed at understanding mechanisms and developing new therapeutic options for cardiometabolic disease treatment and prevention.

Keywords: AHA Scientific Statements; diet; metagenomics; microbiota; nutrigenetics; nutrigenomics; nutritional status.

Publication types

  • Review

MeSH terms

  • American Heart Association
  • Animals
  • Biomedical Research / trends*
  • Cardiovascular Diseases / blood
  • Cardiovascular Diseases / genetics
  • Cardiovascular Diseases / microbiology
  • Cardiovascular Diseases / prevention & control*
  • Diet / adverse effects
  • Diffusion of Innovation
  • Epigenesis, Genetic
  • Forecasting
  • Gastrointestinal Microbiome / genetics*
  • Gastrointestinal Tract / microbiology*
  • Gene-Environment Interaction*
  • Genetic Predisposition to Disease
  • Genetic Variation*
  • Host-Pathogen Interactions
  • Humans
  • Metagenomics / trends
  • Nutrigenomics / trends
  • Nutrition Assessment
  • Nutritional Status / genetics*
  • Phenotype
  • Preventive Health Services / trends*
  • Risk Assessment
  • Risk Factors
  • United States