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Review
. 2016 Apr 15;8(4):330-40.
doi: 10.4251/wjgo.v8.i4.330.

MicroRNAs as diagnostic and prognostic biomarkers in colorectal cancer

Rui Yi  1 , Yao Li  1 , Fei-Liang Wang  1 , Gang Miao  1 , Ruo-Mei Qi  1 , Yan-Yang Zhao  1
Affiliations
Free PMC article
Review

MicroRNAs as diagnostic and prognostic biomarkers in colorectal cancer

Rui Yi et al. World J Gastrointest Oncol. .
Free PMC article

Abstract

MicroRNAs (miRNAs) are key regulators involved in various tumors. They regulate cell cycle, apoptosis and cancer stemness, metastasis and chemoresistance by controlling their target gene expressions. Here, we mainly discuss the potential uses of miRNAs in colorectal cancer (CRC) diagnosis. We also shed light on the important corresponding miRNA targets and on the major regulators of miRNAs. Furthermore, we discuss miRNA activity in assessing the prognosis and recurrence of CRC as well as in modulating responsiveness to chemotherapy. Based on the various pro-oncogenic/anti-oncogenic roles of miRNAs, the advantages of a therapeutic strategy based on the delivery of miRNA mimics are also mentioned. Together, miRNA seems to be an excellent tool for effectively monitoring and targeting CRC.

Keywords: Biomarkers; Colorectal cancer; Diagnosis; MicroRNA; Prognosis.

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