Electrostatic Repulsion Governs TDP-43 C-terminal Domain Aggregation

PLoS Biol. 2016 Apr 20;14(4):e1002447. doi: 10.1371/journal.pbio.1002447. eCollection 2016 Apr.


TDP-43 is a protein that forms aggregates implicated in amyotrophic lateral sclerosis. In response to a recent study, this Formal Comment argues that the pH-dependent solubility of this protein is better explained by the mutual repulsion of charged groups than by the formation of hydrogen bonds.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Amyotrophic Lateral Sclerosis / genetics*
  • DNA-Binding Proteins / metabolism*
  • Humans


  • DNA-Binding Proteins

Grant support

Supported by Grants SAF2013-49179-C2-2-R (DVL), EU Joint Programme-Neurodegenerative Diseases grants RiMod-FTD, Ministerio della Sanita' (EB), and AC14/00037 (DVL) & Thierry Latran Foundation (REHNPALS) (EB). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.