TDP-43 is a protein that forms aggregates implicated in amyotrophic lateral sclerosis. In response to a recent study, this Formal Comment argues that the pH-dependent solubility of this protein is better explained by the mutual repulsion of charged groups than by the formation of hydrogen bonds.
Research Support, Non-U.S. Gov't
Amyotrophic Lateral Sclerosis / genetics*
DNA-Binding Proteins / metabolism*
Supported by Grants SAF2013-49179-C2-2-R (DVL), EU Joint Programme-Neurodegenerative Diseases grants RiMod-FTD, Ministerio della Sanita' (EB), and AC14/00037 (DVL) & Thierry Latran Foundation (REHNPALS) (EB). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.