Cutaneous Small/Medium CD4+ Pleomorphic T-Cell Lymphoma-Like Nodule in a Patient With Erythema Chronicum Migrans

Am J Dermatopathol. 2016 Jun;38(6):448-52. doi: 10.1097/DAD.0000000000000596.


CD4+ small/medium pleomorphic T-cell lymphoma is a relatively rare subtype of cutaneous lymphoproliferative disorder with an indolent clinical behavior. The place of this condition among lymphomas is debatable. The authors describe a rare case of the direct association of CD4 small/medium pleomorphic T-cell lymphoma-like solitary nodule with Borrelia burgdorferi infection in a 5-year-old boy, discuss the reactive nature of this condition, and emphasize the importance of clinicopathological correlation.

Publication types

  • Case Reports

MeSH terms

  • CD4-Positive T-Lymphocytes / immunology*
  • Child, Preschool
  • Diagnosis, Differential
  • Erythema Chronicum Migrans / immunology*
  • Erythema Chronicum Migrans / pathology*
  • Humans
  • Lymphoma, T-Cell, Cutaneous / immunology
  • Lymphoma, T-Cell, Cutaneous / pathology*
  • Male
  • Skin Neoplasms / immunology
  • Skin Neoplasms / pathology*