Influence of single nucleotide polymorphisms in the BCL11A and HBS1L-MYB gene on the HbF levels and clinical severity of sickle cell anaemia patients

Ann Hematol. 2016 Jun;95(7):1201-3. doi: 10.1007/s00277-016-2675-1. Epub 2016 Apr 20.

Authors

Dipti Upadhye¹, Dipty Jain², Yogesh Trivedi², Anita Nadkarni¹, Kanjaksha Ghosh¹, Roshan Colah³

Affiliations

¹ National Institute of Immunohaematology, (Indian Council of Medical Research), 13th floor, New Multistoried Building, K.E.M. Hospital Campus, Parel, Mumbai, 400012, India.
² Government Medical College, Nagpur, 440003, India.
³ National Institute of Immunohaematology, (Indian Council of Medical Research), 13th floor, New Multistoried Building, K.E.M. Hospital Campus, Parel, Mumbai, 400012, India. colahrb@gmail.com.

PMID: 27098811
DOI: 10.1007/s00277-016-2675-1

No abstract available

Publication types

Letter

MeSH terms

Adult
Anemia, Sickle Cell / diagnosis
Anemia, Sickle Cell / genetics*
Carrier Proteins / genetics*
Cohort Studies
Female
Fetal Hemoglobin / genetics*
Follow-Up Studies
GTP-Binding Proteins / genetics*
Genes, myb / genetics*
HSP70 Heat-Shock Proteins / genetics*
Humans
Male
Nuclear Proteins / genetics*
Peptide Elongation Factors / genetics*
Polymorphism, Single Nucleotide / genetics*
Repressor Proteins
Severity of Illness Index

Substances

BCL11A protein, human
Carrier Proteins
HSP70 Heat-Shock Proteins
Nuclear Proteins
Peptide Elongation Factors
Repressor Proteins
Fetal Hemoglobin
GTP-Binding Proteins
HBS1L protein, human