Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Mar;5(1):57-64.
doi: 10.1159/000442440. Epub 2016 Jan 16.

Lack of Association Between Selenium Status and Disease Severity and Activity in Patients With Graves' Ophthalmopathy

Affiliations
Free PMC article

Lack of Association Between Selenium Status and Disease Severity and Activity in Patients With Graves' Ophthalmopathy

Nora Dehina et al. Eur Thyroid J. .
Free PMC article

Abstract

Background: Selenium (Se) is of importance for regular functioning of the immune system and thyroid gland, and may have a health effect in mild Graves' ophthalmopathy (GO).

Objective: As the Se status declines in inflammation, we analyzed whether GO activity or severity affects the Se status of patients.

Methods: Serum Se and selenoprotein P (SePP) concentrations were retrospectively determined in 84 consecutive GO patients before treatment and compared to their clinical activity score (CAS) and severity of eye changes (NOSPECS) status, and to the concentrations of autoantibodies targeting the TSH receptor (TRAK) or the IGF1 receptor (IGF1R-aAB).

Results: Serum Se and SePP were linearly associated, indicating a suboptimal Se status of our patients. In comparison to data from other European cohorts, the majority of GO patients had a relatively poor Se status ([Se] ± SD; 70.0 ± 23.8 µg/l), below the threshold needed for full expression of selenoproteins. TRAK were inversely associated with Se concentrations, while IGF1R-aAB titers were not associated with Se. Neither Se nor SePP concentrations differed between GO patients with severe versus mild or active versus inactive disease, or showed significant associations with the CAS or NOSPECS values.

Conclusion: GO patients are at risk of a low Se status, yet disease severity or activity does not seem to affect Se or SePP concentrations directly. However, as the retrospective nature of the analysis does not allow conclusions on a potential causative role of Se on Graves' disease or GO risk, these results neither support nor discourage adjuvant Se supplementation attempts.

Keywords: Autoimmunity; Exophthalmos; Graves’ disease; Selenoprotein P; Thyroid.

Figures

Fig. 1
Fig. 1
Correlations of biomarkers of Se status with thyroid hormones. Se and SePP were determined in sera from GO patients. a Se and SePP showed a strong positive correlation (R2 = 0.376; p < 0.0001) indicating a relative Se deficiency of the patients. Serum SePP and fT4 (b) and serum Se and fT4 (c) were not significantly associated. Four data points >50 pmol/l fT4 are not indicated in b and c for reasons of scale.
Fig. 2
Fig. 2
Correlations of biomarkers of Se status with GO-specific parameters. Disease severity and activity of GO patients were classified by CAS and NOSPECS values. Serum SePP and CAS (a) and SePP and NOSPECS (b) were not significantly associated. Similarly, there was no correlation between serum Se and CAS (c) or Se and NOSPECS (d).
Fig. 3
Fig. 3
Correlation of Se status with autoantibody concentrations. a Serum SePP concentrations showed a nonsignificant tendency to negatively correlate with TRAK concentrations. b Serum Se concentrations showed a significant negative correlation with TRAK concentrations. There were no significant correlations of serum SePP (c) or Se (d) status with IGF1R-aAB concentrations.

Similar articles

See all similar articles

Cited by 10 articles

See all "Cited by" articles
Feedback