Inflammation and endometriosis

Front Biosci (Landmark Ed). 2016 Jun 1;21:941-8. doi: 10.2741/4431.

Abstract

Endometriosis is defined by presence of endometrial glands and stroma outside the uterine cavity and it affects approximately 5%-10% of women of reproductive age. Although endometriosis is usually considered to be due to retrograde menstruation, the true pathogenesis of this disease remains poorly understood. Endometriosis is associated with an inflammatory response and this inflammation leads to endothelial dysfunction and might even lead to carcinogenesis. Here, we review our current understanding of the role of inflammatory processes in the pathogenesis of endometriosis.

Publication types

  • Review

MeSH terms

  • Animals
  • Chemokine CCL5 / immunology
  • Endometriosis / etiology*
  • Endometriosis / immunology
  • Endometriosis / pathology
  • Female
  • Humans
  • Inflammation / complications*
  • Inflammation / immunology
  • Inflammation / pathology
  • Lymphocyte Activation
  • T-Lymphocyte Subsets / immunology

Substances

  • CCL5 protein, human
  • Chemokine CCL5