The aim of this prospective study was to demonstrate the feasibility of the conic coupling connection as a novel approach for the retention of immediately loaded, titanium-reinforced, temporary fixed partial restorations. The patients received a fixed, immediate partial restoration, attached using the conic coupling connection to two implants placed in a fresh extraction socket. Changes in marginal peri-implant bone level or probing depth measurements, biologic or technical complications, and any other adverse event were recorded at yearly follow-ups up to 3 years after implantation. A total of 78 implants placed in 39 patients reached the 3-year follow-up. A trend of bone overgrowth over the implant platform (mean: 0.2 mm) and a complete fill of the vertical gap between the implant platform level and the first point of contact of the bone with the implant surface was seen after the 6-month follow-up. No disconnection of any prosthesis was noted during 3 years of full occlusal function. The results of this study suggest that titanium-reinforced, temporary partial restorations with conic coupling retention supported by immediate implants provide a successful, cost-effective treatment modality.