Induction of beta-polymerase mRNA by DNA-damaging agents in Chinese hamster ovary cells

Mol Cell Biol. 1989 Feb;9(2):851-3. doi: 10.1128/mcb.9.2.851-853.1989.


Only a few of the genes involved in DNA repair in mammalian cells have been isolated, and induction of a DNA repair gene in response to DNA damage has not yet been established. DNA polymerase beta (beta-polymerase) appears to have a synthetic role in DNA repair after certain types of DNA damage. Here we show that the level of beta-polymerase mRNA is increased in CHO cells after treatment with several DNA-damaging agents.

MeSH terms

  • Animals
  • Cells, Cultured
  • Cricetinae
  • Cricetulus
  • DNA Damage*
  • DNA Polymerase I / biosynthesis
  • DNA Polymerase I / genetics*
  • Female
  • Gene Expression Regulation / drug effects
  • Gene Expression Regulation / radiation effects
  • Methyl Methanesulfonate
  • Methylnitronitrosoguanidine
  • Ovary
  • RNA, Messenger / biosynthesis
  • RNA, Messenger / genetics*
  • Ultraviolet Rays


  • RNA, Messenger
  • Methylnitronitrosoguanidine
  • Methyl Methanesulfonate
  • DNA Polymerase I