Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Nov;46(11):1689-1697.
doi: 10.1007/s40279-016-0543-8.

Effects of Resistance Training Frequency on Measures of Muscle Hypertrophy: A Systematic Review and Meta-Analysis


Effects of Resistance Training Frequency on Measures of Muscle Hypertrophy: A Systematic Review and Meta-Analysis

Brad J Schoenfeld et al. Sports Med. .


Background: A number of resistance training (RT) program variables can be manipulated to maximize muscular hypertrophy. One variable of primary interest in this regard is RT frequency. Frequency can refer to the number of resistance training sessions performed in a given period of time, as well as to the number of times a specific muscle group is trained over a given period of time.

Objective: We conducted a systematic review and meta-analysis to determine the effects of resistance training frequency on hypertrophic outcomes.

Methods: Studies were deemed eligible for inclusion if they met the following criteria: (1) were an experimental trial published in an English-language refereed journal; (2) directly compared different weekly resistance training frequencies in traditional dynamic exercise using coupled concentric and eccentric actions; (3) measured morphologic changes via biopsy, imaging, circumference, and/or densitometry; (4) had a minimum duration of 4 weeks; and (5) used human participants without chronic disease or injury. A total of ten studies were identified that investigated RT frequency in accordance with the criteria outlined.

Results: Analysis using binary frequency as a predictor variable revealed a significant impact of training frequency on hypertrophy effect size (P = 0.002), with higher frequency being associated with a greater effect size than lower frequency (0.49 ± 0.08 vs. 0.30 ± 0.07, respectively). Statistical analyses of studies investigating training session frequency when groups are matched for frequency of training per muscle group could not be carried out and reliable estimates could not be generated due to inadequate sample size.

Conclusions: When comparing studies that investigated training muscle groups between 1 to 3 days per week on a volume-equated basis, the current body of evidence indicates that frequencies of training twice a week promote superior hypertrophic outcomes to once a week. It can therefore be inferred that the major muscle groups should be trained at least twice a week to maximize muscle growth; whether training a muscle group three times per week is superior to a twice-per-week protocol remains to be determined.

Similar articles

See all similar articles

Cited by 21 articles

See all "Cited by" articles


    1. Med Sci Sports Exerc. 2004 Apr;36(4):674-88 - PubMed
    1. Sports Med. 2007;37(3):225-64 - PubMed
    1. J Strength Cond Res. 2010 Oct;24(10):2857-72 - PubMed
    1. Int J Sport Nutr Exerc Metab. 2015 Dec;25(6):559-65 - PubMed
    1. J Sports Med Phys Fitness. 2015 Mar;55(3):144-9 - PubMed

MeSH terms