Importance of the alternative NF-κB activation pathway in inflammation-associated gastrointestinal carcinogenesis

Am J Physiol Gastrointest Liver Physiol. 2016 Jun 1;310(11):G1081-90. doi: 10.1152/ajpgi.00026.2016. Epub 2016 Apr 21.


Chronic inflammation is a common factor in the development of many gastrointestinal malignancies. Examples include inflammatory bowel disease predisposing to colorectal cancer, Barrett's esophagus as a precursor of esophageal adenocarcinoma, and Helicobacter pylori-induced gastric cancer. The classical activation pathway of NF-κB signaling has been identified as regulating several sporadic and inflammation-associated gastrointestinal tract malignancies. Emerging evidence suggests that the alternative NF-κB signaling pathway also exerts a distinct influence on these processes. This review brings together current knowledge of the role of the alternative NF-κB signaling pathway in the gastrointestinal tract, with a particular emphasis on inflammation-associated cancer development.

Keywords: Helicobacter pylori; colitis; gastric cancer; nuclear factor-κB.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Gastrointestinal Neoplasms / complications
  • Gastrointestinal Neoplasms / epidemiology
  • Gastrointestinal Neoplasms / metabolism*
  • Humans
  • Inflammatory Bowel Diseases / complications
  • Inflammatory Bowel Diseases / metabolism*
  • NF-kappa B / genetics
  • NF-kappa B / metabolism*
  • Signal Transduction*


  • NF-kappa B