Gamma glutamyltransferase and risk of future dementia in middle-aged to older Finnish men: A new prospective cohort study

Alzheimers Dement. 2016 Sep;12(9):931-941. doi: 10.1016/j.jalz.2016.03.003. Epub 2016 Apr 18.


Introduction: We assessed the association of gamma glutamyltransferase (GGT) with risk of dementia.

Methods: Serum GGT activity was assessed at baseline in the Kuopio Ischemic Heart Disease prospective cohort of 2415 relatively healthy men with good cognitive function. Correction was made for within-person variability in GGT levels.

Results: During an average follow-up of 22 years, 219 new cases of dementia were recorded. Serum GGT was log-linearly associated with risk of dementia. The hazard ratio (HR) (95% CIs) for dementia per 1 standard deviation (SD) higher baseline loge GGT values was 1.33 (95% CI = 1.14-1.55) after adjustment for several established and emerging risk factors. The corresponding HR was 1.52 (95% CI = 1.22-1.89) after correction for within-person variability.

Discussion: GGT is positively, log-linearly, and independently associated with future risk of dementia in the general male population. Further research is needed to unravel the mechanistic pathways of GGT in the pathogenesis of dementia.

Keywords: Dementia; Gamma glutamyltransferase; Risk factor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Biomarkers / blood
  • Dementia / blood*
  • Dementia / epidemiology*
  • Finland / epidemiology
  • Follow-Up Studies
  • Humans
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Proportional Hazards Models
  • Prospective Studies
  • Risk Factors
  • gamma-Glutamyltransferase / blood*


  • Biomarkers
  • gamma-Glutamyltransferase